2025

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Cojocaru AI, Kefi K, Masson JD, Tiret L, Relaix F, Taglietti V. Forskolin treatment enhances muscle regeneration and shows therapeutic potential with limitations in Duchenne muscular dystrophy. Skeletal Muscle 15, 12 (2025). https://doi.org/10.1186/s13395-025-00381-7

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Masson JD, Taglietti V, Ruby F, no H, Mouri N, Jorge A, Guillaud L, Tiret L, Relaix F. Extensive Striated Muscle Damage in a Rat Model of Duchenne Muscular Dystrophy with Dmd Exon 10-17 Duplication. Skeletal Muscle (2025).

 

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2024

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Barthélémy I, Su JB, Cauchois X, Relaix F, Ghaleh B, Blot S. Ambulatory electrocardiographic longitudinal monitoring in a canine model for Duchenne muscular dystrophy identifies decreased very low frequency power as a hallmark of impaired heart rate variability. Sci Rep. 2024 Apr 18;14(1):8969. doi: 10.1038/s41598-024-59196-z. PMID: 38637619; PMCID: PMC11026469.

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Bou Akar R, Lama C, Aubin D, Maruotti J, Onteniente B, Esteves de Lima J, Relaix F. Generation of highly pure pluripotent stem cell-derived myogenic progenitor cells and myotubes. Stem Cell Reports. 2024 Jan 9;19(1):84-99. doi: 10.1016/j.stemcr.2023.11.002. Epub 2023 Dec 14. PMID: 38101399; PMCID: PMC10828960.

 

Chrysostomou E, Mourikis P. “The extracellular matrix niche of muscle stem cells”. Review with original data. Curr Top Dev Biol. (2024).

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Hubregtse L, Bouman K, Lama C, Lassche S, de Graaf N, Taglietti V, Küsters B, Periou B, Relaix F, van Engelen B, Authier FJ, Voermans NC, Malfatti E. An up-to-date myopathologic characterisation of facioscapulohumeral muscular dystrophy type 1 muscle biopsies shows sarcolemmal complement membrane attack complex deposits and increased skeletal muscle regeneration. Neuromuscul Disord. 2024 Mar;36:6-15. doi: 10.1016/j.nmd.2024.01.003. Epub 2024 Jan 14. PMID: 38306719.

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Onnée M, Bénézit A, Bastu S, Nadaj-Pakleza A, Lannes B, Ader F, Thèze C, Cintas P, Cances C, Carlier RY, Metay C, Cossée M, Malfatti E. The FLNC Ala1186Val Variant Linked to Cytoplasmic Body Myopathy and Cardiomyopathy Causes Protein Instability. Biomedicines. 2024 Jan 30;12(2):322. doi: 10.3390/biomedicines12020322. PMID: 38397924; PMCID: PMC10887408.

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Ozturk T, Mignot J, Gattazzo F, Gervais M, Relaix F, Rouard H, Didier N. Dual inhibition of P38 MAPK and JNK pathways preserves stemness markers and alleviates premature activation of Muscle Stem Cells during isolation. Stem Cell Research and Therapy. 2024 Jun 21;15(1):179.

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Taglietti V, Kefi K, Mirciloglu B, Bastu S, Masson JD, Bronisz-Budzyńska I, Gouni V, Ferri C, Jorge A, Gentil C, Pietri-Rouxel F, Malfatti E, Lafuste P, Tiret L, Relaix F. Progressive cardiomyopathy with intercalated disc disorganization in a rat model of Becker dystrophy. EMBO Rep. 2024 Oct 2. doi: 10.1038/s44319-024-00249-9. Epub ahead of print. PMID: 39358550.

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2023

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Cardone N*, Taglietti V*, Baratto S, Kefi K, Periou B, Gitiaux C, Barnerias C, Lafuste P, Leturcq F, Nectoux J, Panicucci C, Desguerre I, Bruno C, Authier FJ, Fiorillo C, Relaix F, Malfatti E. Myopathologic trajectory in Duchenne Muscular Dystrophy (DMD) reveals lack of regeneration due to senescence in satellite cells. Acta neuropathologica communications 11, 167 (2023).

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Bencze M, B. Periou , I. Punzón , I. Barthélémy , V. Taglietti , C. Hou , L. Zaidan, K. Kefi , S. Blot , O. Agbulut , M. Gervais , G. Derumeaux , FJ. Authier, L.Tiret, F. Relaix, Receptor-interacting protein kinase-3 mediates both myopathy and cardiomyopathy in preclinical animal models of Duchenne muscular Dystrophy, Journal of Cachexia, Sarcopenia and Muscle (2023) In press. DOI: 10.1002/jcsm.13265

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Bencze M, Mechanisms of Myofibre Death in Muscular Dystrophies: The Emergence of the Regulated Forms of Necrosis in Myology, Int J Mol Science (2023). DOI: 10.3390/ijms24010362

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Brelle L, Faÿ F, Ozturk T, Didier N, Renard E, Langlois V. Hydrogel Based on Polyhydroxyalkanoate Sulfonate: Control of the Swelling Rate by the Ionic Group Content. Biomacromolecules. 2023 Apr 10;24(4):1871-1880.

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Cardone N, Moula M, Baelde RJ, Biquand A, Villanova M, Metay C, Fiorillo C, Baratto S, Merlini L, Sabatelli P, Romero NB, Relaix F, Authier FJ, Taglietti V, Savarese M, de Winter J, Ottenheijm C, Richard I, Malfatti E. Clinical and functional characterization of a long survivor congenital titinopathy patient with a novel metatranscript-only titin variant. Acta Neuropathol Commun. 2023 Mar 21;11(1):48. doi: 10.1186/s40478-023-01539-4. PMID: 36945066

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Khadhraoui, N., Prola, A., Vandestienne, A., Blondelle, J., Guillaud, L., Courtin, G., Bodak, M., Prost, B., Huet, H., Wintrebert, M., Péchoux, C., Solgadi, A., Relaix, F., Tiret, L., Pilot-Storck, F., 2023. Hacd2 deficiency in mice leads to an early and lethal mitochondrial disease. Molecular Metabolism 69, 101677. https://doi.org/10.1016/j.molmet.2023.101677

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Marignac G, Pilot-Storck F. Body, ambient and felt temperature: An attempt to resolve a human and mice dilemma. Biochimie. 2023 Jul;210:99-104. doi: 10.1016/j.biochi.2023.05.005. Epub 2023 May 19. PMID: 37211254 Review.

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Nekooie Marnany N, Fodil R, Féréol S, Dady A, Depp M, Relaix F, Motterlini R, Foresti R, Duband JL, Dufour S. Glucose oxidation drives trunk neural crest cell development and fate. J Cell Sci. 2023 Aug 15;136(16):jcs260607. doi: 10.1242/jcs.260607. Epub 2023 Aug 15. PMID: 37589341

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Taglietti V, Kefi K, Rivera L, Bergiers O, Cardone N, Coulpier F, Gioftsidi S, Drayton-Libotte B, Hou C, Authier FJ, Pietri-Rouxel F, Robert M, Bremond-Gignac D, Bruno C, Fiorillo C, Malfatti E, Lafuste P, Tiret L, Relaix F. Thyroid-stimulating hormone receptor signaling restores skeletal muscle stem cell regeneration in rats with muscular dystrophy. Sci Transl Med. 2023 Mar;15(685):eadd5275. doi: 10.1126/scitranslmed.add5275. Epub 2023 Mar 1. PMID: 36857434

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Tajbakhsh S, Relaix F. Advances in skeletal myogenesis: from molecular regulation to cell biology and pathology. Exp Cell Res. 2023 Mar 1;424(1):113457. doi: 10.1016/j.yexcr.2023.113457. Epub 2023 Jan 3. PMID: 36608838

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Vignais ML, Levoux J, Sicard P, Khattar K, Lozza C, Gervais M, Mezhoud S, Nakhle J, Relaix F, Agbulut O, Fauconnier J, Rodriguez AM. Transfer of Cardiac Mitochondria Improves the Therapeutic Efficacy of Mesenchymal Stem Cells in a Preclinical Model of Ischemic Heart Disease. Cells. 2023 Feb 11;12(4):582. doi: 10.3390/cells12040582. PMID: 36831249

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Zaidan L, Geara P, Borok MJ, Machado L, Mademtzoglou D, Mourikis P, Relaix F. Unfractionated Bulk Culture of Mouse Skeletal Muscle to Recapitulate Niche and Stem Cell Quiescence. J Vis Exp. 2023 Jun 2;(196). doi: 10.3791/65433. PMID: 37335124

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2022

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Taglietti V, Kefi K, Bronisz-Budzyńska I, Mirciloglu B, Rodrigues M, Cardone N, Coulpier F, Periou B, Gentil C, Goddard M, Authier FJ, Pietri-Rouxel F, Malfatti E, Lafuste P, Tiret L, Relaix F. Duchenne muscular dystrophy trajectory in R-DMDdel52 preclinical rat model identifies COMP as biomarker of fibrosis. Acta Neuropathol Commun. 2022 Apr 25;10(1):60. 

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Pérez-Díaz S, Koumaiha Z, Borok MJ, Aurade F, Pini M, Periou B, Rouault C, Baba-Amer Y, Clément K, Derumeaux G, Authier FJ, Lafuste P, Relaix F. Obesity impairs skeletal muscle repair through NID-1 mediated extracellular matrix remodeling by mesenchymal progenitors. Matrix Biol. 2022: Sep;112:90-115.

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Böhm J, I Barthélémy, C Landwerlin, N Blanchard-Gutton, F Relaix, S Blot, J Laporte, L Tiret. (2022). A dog model for centronuclear myopathy (CNM) carrying the most common DNM2 mutation. Dis Model Mech. Mar 4:dmm.049219. doi: 10.1242/dmm.049219. PMID: 35244154

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Gioftsidi S, Relaix F, Mourikis P. The Notch signaling network in muscle stem cells during development, homeostasis, and disease. Skelet Muscle. 2022 Apr 22;12(1):9. doi: 10.1186/s13395-022-00293-w. PMID: 35459219; PMCID: PMC9027478.

 

Gómez-García de la Banda M, Simental-Aldaba E, Fahmy N, Sternberg D, Blondy P, Quijano-Roy S, Malfatti E. Case Report: A Novel AChR Epsilon Variant Causing a Clinically Discordant Salbutamol Responsive Congenital Myasthenic Syndrome in Two Egyptian Siblings. Front Neurol. 2022 Jun 2;13:909715. doi: 10.3389/fneur.2022.909715. PMID: 35720108; PMCID: PMC9201482.

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2021

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Santos MD, Gioftsidi S, Backer S, Machado L, Relaix F, Maire P, Mourikis P. Extraction and sequencing of single nuclei from murine skeletal muscles. STAR Protoc. 2021: 2(3):100694. PMID: 34382019

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Esteves de Lima J, Bou Akar R, Machado L, Li Y, Drayton-Libotte B, Dilworth FJ, Relaix F. HIRA stabilizes skeletal muscle lineage identity. Nat Commun. 2021: 12(1):3450. PMID: 34103504

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Esteves de Lima J, Blavet C, Bonnin MA, Hirsinger E, Comai G, Yvernogeau L, Delfini MC, Bellenger L, Mella S, Nassari S, Robin C, Schweitzer R, Fournier-Thibault C, Jaffredo T, Tajbakhsh S, Relaix F, Duprez D. Unexpected contribution of fibroblasts to muscle lineage as a mechanism for limb muscle patterning. Nat Commun. 2021: 12(1):3851. PMID: 34158501

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Machado L, Relaix F, Mourikis P. Stress relief: emerging methods to mitigate dissociation-induced artefacts. Trends Cell Biol. 2021: S0962-8924(21)00096-9. PMID: 34074577

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Julien A, Kanagalingam A, Martínez-Sarrà E, Megret J, Luka M, Ménager M, Relaix F, Colnot C. Direct contribution of skeletal muscle mesenchymal progenitors to bone repair. Nat Commun. 2021: 2860. PMID: 34001878

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Esteves de Lima J, Bou Akar R, Mansour M, Rocancourt D, Buckingham M, Relaix F. M-Cadherin Is a PAX3 target during myotome patterning. Front Cell Dev Biol. 9: 652652. PMID: 33869209

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Borok M, Didier N, Gattazzo F, Ozturk T, Corneau A, Rouard H, Relaix F. Progressive and coordinated mobilization of the skeletal muscle niche throughout tissue repair revealed by single-cell proteomic analysis. Cells. 10(4): 744. PMID: 33800595

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Machado L*, Geara P*, Camps J, Dos Santos M, Teixeira-Clerc F, Van Herck J, Varet H, Legendre R, Pawlotsky JM, Sampaolesi M, Voet T, Maire P, Relaix F, Mourikis P. Tissue damage induces a conserved stress response that initiates quiescent muscle stem cell activation. Cell Stem Cell. S1934-5909(21)00017-5. PMID: 33609440

 

Prola A, Blondelle J, Vandestienne A, Piquereau J, Denis RGP, Guyot S, Chauvin H, Mourier A, Maurer M, Henry C, Khadhraoui N, Gallerne C, Molinie T, Courtin G, Guillaud L, Gressette M, Solgadi A, Dumont F, Castel J, Ternacle J, Demarquoy J, Malgroyre A, Loulmann N, Derumeaux G, Giraud MF, Joubert F, Beksier V, Luquet S, Relaix F, Tiret L, Pilot-Storck F. Cardiolipin content controls mitochondrial coupling and energetic efficiency in muscle. Sci Adv. 7(1):eabd6322. PMID: 30194302

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Relaix F, Bencze M, Borok MJ, Der Vartanian A, Gattazzo F, Mademtzoglou D, Perez-Diaz S, Prola A, Reyes-Fernandez PC, Rotini A, Taglietti V. Perspectives on skeletal muscle stem cells. Nat Commun. 12(1):692. PMID: 33514709

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Levoux J, Prola A, Lafuste P, Gervais M, Chevallier N, Koumaiha Z, Kefi K, Braud L, Schmitt A, Yacia A, Schirmann A, Hersant B, Sid-Ahmed M, Ben Larbi S, Komrskova K, Rohlena J, Relaix F, Neuzil J, Rodriguez AM. Platelets facilitate the wound-healing capability of mesenchymal stem cells by mitochondrial transfer and metabolic reprogramming. Cell Metab. S1550-4131(20):30661-6. PMID: 3340911

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