PUBLICATIONS
Relaix Lab publications since 2014
PUBLICATIONS
Relaix Lab publications since 2014
2020
Gattazzo F, Laurent B, Relaix F, Rouard H, Didier N. Distinct phases of postnatal skeletal muscle growth govern the progressive establishment of muscle stem cell quiescence. Stem Cell Reports. S2213-6711(20)30288-5. PMID: 32763161
Besse A, Astord S, Marais T, Roda M, Giroux B, Lejeune FX, Relaix F, Smeriglio P, Barkats M, Biferi MG. AAV9-mediated expression of SMN restricted to neurons does not rescue the Spinal Muscular Atrophy phenotype in mice. Mol Ther. 28(8). 1887-1901. PMID: 32470325
Borok MJ, Mademtzoglou D, Relaix F. Bu-M-P-ing iron: How BMP signaling regulates muscle growth and regeneration. J Dev Biol. 8(1). pii: E4. PMID: 32053985
2019
Der Vartanian A, Quétin M, Michineau S, Auradé F, Hayashi S, Dubois C, Rocancourt D, Drayton-Libotte B, Szegedi A, Buckingham M, Conway SJ, Gervais M, Relaix F. Pax3 confers functional heterogeneity in skeletal muscle stem cell responses to environmental stress. Cell Stem Cell. pii: S1934-5909(19)30118-3. PMID: 31006622
Yvernogeau L, Gautier R, Petit L, Khoury H, Relaix F, Ribes V, Sang H, Charbord P, Souyri M, Robin C, Jaffredo T. In vivo generation of haematopoietic stem/progenitor cells from bone marrow-derived haemogenic endothelium. Nat Cell Biol. 21(11): 1334-1345. PMID: 31685991
Reyes-Fernandez PC, Periou B, Decrouy X, Relaix F, Authier FJ. Automated image-analysis method for the quantification of fiber morphometry and fiber type population in human skeletal muscle. Skelet Muscle. 9(1): 15. PMID: 31133066
2018
Baghdadi MB, Castel D, Machado L, Fukada SI, Birk DE, Relaix F, Tajbakhsh S, Mourikis P. Reciprocal signalling by Notch-Collagen V-CALCR retains muscle stem cells in their niche. Nature. 557(7707):714-718. PMID: 29795344
Mademtzoglou D, Asakura Y, Borok MJ, Alonso-Martin S, Mourikis P, Kodaka Y, Mohan A, Asakura A, Relaix F. Cellular localization of the cell cycle inhibitor Cdkn1c controls growth arrest of adult skeletal muscle stem cells. Elife. 7. pii: e33337. PMID: 30284969
Alonso-Martin S, Auradé F, Mademtzoglou D, Rochat A, Zammit PS, Relaix F. SOXF factors regulate murine satellite cell self-renewal and function through inhibition of β-catenin activity. Elife. 7. pii: e26039. PMID: 29882512
Morgan JE, Prola A, Mariot V, Pini V, Meng J, Hourde C, Dumonceaux J, Conti F, Relaix F, Authier FJ, Tiret L, Muntoni F, Bencze M. Necroptosis mediates myofibre death in dystrophin-deficient mice. Nat Commun. 9(1): 3655. PMID: 30194302
Taglietti V, Angelini G, Mura G, Bonfanti C, Caruso E, Monteverde S, Le Carrou G, Tajbakhsh S, Relaix F, Messina G. RhoA and ERK signalling regulate the expression of the transcription factor Nfix in myogenic cells. Development. 145(21). PMID: 30266829
Relaix F, Machado L. Waking up muscle stem cells: PI3K signalling is ringing. EMBO J. 37(8). pii: e99297. PMID: 29581098
2017
Machado L, Esteves de Lima J, Fabre O, Proux C, Legendre R, Szegedi A, Varet H, Ingerslev LR, Barrès R, Relaix F*, Mourikis P. *corresponding author. In situ fixation redefines quiescence and early activation of skeletal muscle stem cells. Cell Rep. 21(7):1982-1993. PMID: 29141227
Banerji CRS, Panamarova M, Hebaishi H, White RB, Relaix F, Severini S, Zammit PS. PAX7 target genes are globally repressed in facioscapulohumeral muscular dystrophy skeletal muscle. Nat Commun. 8(1):2152. PMID: 29255294
Stantzou A, Schirwis E, Swist S, Alonso-Martin S, Polydorou I, Zarrouki F, Mouisel E, Beley C, Julien A, Le Grand F, Garcia L, Colnot C, Birchmeier C, Braun T, Schuelke M, Relaix F, Amthor H. BMP signaling regulates satellite cell-dependent postnatal muscle growth. Development. 144(15): 2737-2747. PMID: 28694257
Scionti I, Hayashi S, Mouradian S, Girard E, Esteves de Lima J, Morel V, Simonet T, Wurmser M, Maire P, Ancelin K, Metzger E, Schüle R, Goillot E, Relaix F, Schaeffer L. LSD1 controls timely MyoD expression via MyoD core enhancer transcription. Cell Rep. 18(8): 1996-2006. PMID: 28228264
Vallecillo-García P, Orgeur M, Vom Hofe-Schneider S, Stumm J, Kappert V, Ibrahim DM, Börno ST, Hayashi S, Relaix F, Hildebrandt K, Sengle G, Koch M, Timmermann B, Marazzi G, Sassoon DA, Duprez D, Stricker S. Odd skipped-related 1 identifies a population of embryonic fibro-adipogenic progenitors regulating myogenesis during limb development. Nat Commun. 8(1): 1218. PMID: 29084951
Mademtzoglou D, Alonso-Martin S, Chang TH, Bismuth K, Drayton-Libotte B, Aurade F, Relaix F. A p57 conditional mutant allele that allows tracking of p57-expressing cells.Genesis. 55(4). PMID: 28196404
2016
Hayashi S, Manabe I, Suzuki Y, Relaix F, Oishi Y. Klf5 regulates muscle differentiation by directly targeting muscle-specific genes in cooperation with MyoD in mice. Elife. 2016;5. PMID: 27743478
Machado L, Relaix F. Heterochromatin compaction is regulated by Suv4-20h1 to maintains skeletal muscle stem cells quiescence. Stem Cell Investig. 2016;3:23. PMID: 27488816
Alonso-Martin S, Rochat A, Mademtzoglou D, Morais J, de Reyniès A, Auradé F, Chang TH, Zammit PS, Relaix F. Gene expression profiling of muscle stem cells identifies novel regulators of postnatal myogenesis. Front Cell Dev Biol. 2016;4:58. PMID: 27446912
Mourikis P, Relaix F. Activated muscle satellite cells chase ghosts. Cell Stem Cell. 18(2): 160-2. PMID: 26849298
Smeriglio P, Alonso-Martin S, Masciarelli S, Madaro L, Iosue I, Marrocco V, Relaix F, Fazi F, Marazzi G, Sassoon DA, Bouché M. Phosphotyrosine phosphatase inhibitor bisperoxovanadium endows myogenic cells with enhanced muscle stem cell functions via epigenetic modulation of Sca-1 and Pw1 promoters. FASEB J. 30(4): 1404-15. PMID: 26672000
2015
Zalc A, Rattenbach R, Auradé F, Cadot B, Relaix F. Pax3 and Pax7 play essential safeguard functions against environmental stress-induced birth defects. Dev Cell. 33(1): 56-66. PMID: 25800090
Buckingham M, Relaix F. PAX3 and PAX7 as upstream regulators of myogenesis. Semin Cell Dev Biol. 44: 115-125. PMID: 26424495
Kostallari E, Baba-Amer Y, Alonso-Martin S, Ngoh P, Relaix F, Lafuste P, Gherardi RK. Pericytes in the myovascular niche promote post-natal myofiber growth and satellite cell quiescence. Development. 2015;142(7):1242-53. PMID: 25742797
Chal J, Oginuma M, Al Tanoury Z, Gobert B, Sumara O, Hick A, Bousson F, Zidouni Y, Mursch C, Moncuquet P, Tassy O, Vincent S, Miyanari A, Bera A, Garnier JM, Guevara G, Hestin M, Kennedy L, Hayashi S, Drayton B, Cherrier T, Gayraud-Morel B, Gussoni E, Relaix F, Tajbakhsh S, Pourquié O. Differentiation of pluripotent stem cells to muscle fiber to model Duchenne muscular dystrophy. Nat Biotechnol. 33(9): 962-969. PMID: 26237517
Blondelle J, Ohno Y, Gache V, Guyot S, Storck S, Blanchard-Gutton N, Barthélémy I, Walmsley G, Rahier A, Gadin S, Maurer M, Guillaud L, Prola A, Ferry A, Aubin-Houzelstein G, Demarquoy J, Relaix F, Piercy RJ, Blot S, Kihara A, Tiret L, Pilot-Storck F. HACD1, a regulator of membrane composition and fluidity, promotes myoblast fusion and skeletal muscle growth. J Mol Cell Biol. 2015;7(5):429-40. PMID: 26160855
2014
Mayeuf-Louchart A, Lagha M, Danckaert A, Rocancourt D, Relaix F, Vincent SD, Buckingham M. Notch regulation of myogenic versus endothelial fates of cells that migrate from the somite to the limb. Proc Natl Acad Sci U S A. 111(24): 8844-8849. PMID: 24927569
Zalc A, Hayashi S, Auradé F, Bröhl D, Chang T, Mademtzoglou D, Mourikis P, Yao Z, Cao Y, Birchmeier C, Relaix F. Antagonistic regulation of p57kip2 by Hes/Hey downstream of Notch signaling and muscle regulatory factors regulates skeletal muscle growth arrest. Development. 141(14): 2780-2790. PMID: 25005473
OUR FOUNDING PILLARS
Selected publications until 2014
Lagha M, Mayeuf-Louchart A, Chang T, Montarras D, Rocancourt D, Zalc A, Kormish J, Zaret KS, Buckingham ME, Relaix F. Itm2a is a Pax3 target gene, expressed at sites of skeletal muscle formation in vivo. PLoS One. 2013; 8(5): e63143. PMID: 23650549
Relaix F, Demignon J, Laclef C, Pujol J, Santolini M, Niro C, Lagha M, Rocancourt D, Buckingham M, Maire P. Six homeoproteins directly activate Myod expression in the gene regulatory networks that control early myogenesis. PLoS Genet. 2013; 9(4): e1003425. PMID: 23637613
Calhabeu F, Hayashi S, Morgan JE, Relaix F, Zammit PS. Alveolar rhabdomyosarcoma-associated proteins PAX3/FOXO1A and PAX7/FOXO1A suppress the transcriptional activity of MyoD-target genes in muscle stem cells. Oncogene. 2013; 32(5): 651-62. PMID: 22710712
Relaix F, Zammit PS. Satellite cells are essential for skeletal muscle regeneration: the cell on the edge returns centre stage. Development. 2012; 139(16): 2845-56. PMID: 22833472
Havis E, Coumailleau P, Bonnet A, Bismuth K, Bonnin MA, Johnson R, Fan CM, Relaix F, Shi DL, Duprez D. Sim2 prevents entry into the myogenic program by repressing MyoD transcription during limb embryonic myogenesis. Development. 2012; 139(11): 1910-20. PMID: 22513369
Van Ho AT, Hayashi S, Bröhl D, Auradé F, Rattenbach R, Relaix F. Neural crest cell lineage restricts skeletal muscle progenitor cell differentiation through Neuregulin1-ErbB3 signaling. Dev Cell. 2011; 21(2): 273-87. PMID: 21782525
Hayashi S, Rocancourt D, Buckingham M, Relaix F. Lack of in vivo functional compensation between Pax family groups II and III in rodents. Mol Biol Evol. 2011; 28(10): 2787-98. PMID: 21512107
Lagha M, Sato T, Regnault B, Cumano A, Zuniga A, Licht J, Relaix F, Buckingham M. Transcriptome analyses based on genetic screens for Pax3 myogenic targets in the mouse embryo. BMC Genomics. 2010; 11: 696. PMID: 21143873
Lagha M, Brunelli S, Messina G, Cumano A, Kume T, Relaix F, Buckingham ME. Pax3:Foxc2 reciprocal repression in the somite modulates muscular versus vascular cell fate choice in multipotent progenitors. Dev Cell. 2009; 17(6): 892-9. PMID: 20059958
Lagha M, Sato T, Bajard L, Daubas P, Esner M, Montarras D, Relaix F, Buckingham M. Regulation of skeletal muscle stem cell behavior by Pax3 and Pax7. Cold Spring Harb Symp Quant Biol. 2008; 73: 307-15. PMID: 19022756
Lagha M, Kormish JD, Rocancourt D, Manceau M, Epstein JA, Zaret KS, Relaix F, Buckingham ME. Pax3 regulation of FGF signaling affects the progression of embryonic progenitor cells into the myogenic program. Genes Dev. 2008; 22(13): 1828-37. PMID: 18593883
Bajard L, Relaix F, Lagha M, Rocancourt D, Daubas P, Buckingham ME. A novel genetic hierarchy functions during hypaxial myogenesis: Pax3 directly activates Myf5 in muscle progenitor cells in the limb. Genes Dev. 2006; 20(17): 2450-6
Zammit PS, Relaix F, Nagata Y, Ruiz AP, Collins CA, Partridge TA, Beauchamp JR. Pax7 and myogenic progression in skeletal muscle satellite cells. J Cell Sci. 2006; 119(Pt 9): 1824-32. PMID: 16608873
Relaix F, Montarras D, Zaffran S, Gayraud-Morel B, Rocancourt D, Tajbakhsh S, Mansouri A, Cumano A, Buckingham M. Pax3 and Pax7 have distinct and overlapping functions in adult muscle progenitor cells. J Cell Biol. 2006; 172(1): 91-102. PMID: 16380438
Montarras D, Morgan J, Collins C, Relaix F, Zaffran S, Cumano A, Partridge T, Buckingham M. Direct isolation of satellite cells for skeletal muscle regeneration. Science. 2005; 309(5743): 2064-7. PMID: 16141372
Relaix F, Rocancourt D, Mansouri A, Buckingham M. A Pax3/Pax7-dependent population of skeletal muscle progenitor cells. Nature. 2005; 435(7044): 948-53. PMID: 15843801
Relaix F, Rocancourt D, Mansouri A, Buckingham M. Divergent functions of murine Pax3 and Pax7 in limb muscle development. Genes Dev. 2004; 18(9): 1088-105. PMID: 15132998
Relaix F, Polimeni M, Rocancourt D, Ponzetto C, Schäfer BW, Buckingham M. The transcriptional activator PAX3-FKHR rescues the defects of Pax3 mutant mice but induces a myogenic gain-of-function phenotype with ligand-independent activation of Met signaling in vivo. Genes Dev. 2003; 17(23): 2950-65. PMID: 14665670