PEOPLE

A Collaborative & International Group

Team director

Prof Fred Relaix

Team director

Research Interests

My research programme aims at deciphering the mechanisms underlying skeletal muscle maintenance and function in physiological or pathogenic conditions such as Duchenne Muscular Dystrophy, preclinical modelling and establishment of innovative therapy with a strong focus on muscle stem cells development and function, impact of environmental stress, muscle stem cell heterogeneity, metabolism and interactions with the niche and local environment.

 

Contact: frederic.relaix {at} inserm.fr

Team

co-director

Philippos

Mourikis, PhD

Academic Researcher (DR)

Research Interests:

Regulation of satellite cell quiescence with a focus on Notch signallng. Using innovative cell isolation techniques, our aim is to identify and characterize the factors that drive satellite cells into quiescence (development/ regeneration), maintain them at this cell state during homeostasis, but also the factors that ignite their activation (regeneration and pathological conditions).

Contact: philippos.mourikis {at} inserm.fr

Fred Relaix

Philippos Mourikis

Financial Assistant

Lila

Bendameche

Financial Assistant

Activities

Financial support to the team for service/product ordering, budgeting, grant follow-up, and new recruits. 

Lila Bendameche

Project

Manager

Despoina

Mademtzoglou, PhD

Project Manager

Research Interests:

Excited to discuss satellite cell-, regeneration-, dystrophy-related projects in the lab and to write grant applications, reports, and conference proposals for these topics.

Contact: despoina.mademtzoglou {at} u-pec.fr

Despoina Mademtzoglou

Academic researchers & Professors

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Jean-Loup

Duband, PhD

Academic Researcher (DR)

Jean-Loup Duband

Sylvie Dufour, PhD

Academic Researcher (DR)

Research Interests:

We develop a multidisciplinary research program, integrating molecular genetics, cell and developmental biology, and mechano-biology to understand how neural crest cells adapt to the metabolic, mechanical and biochemical constraints imposed by their micro environment to regulate their plasticity, migration and cell differentiation during development.

Contact: sylvie.dufour {at} inserm.fr

Sylvie Dufour

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Sophie Fereol, PhD

Associate Professor

Sophie Fereol

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Jules Gilet, PhD

Associate professor

Jules Gilet

Peggy

Lafuste, PhD

Associate Professor

Research Interests

Trying to decipher interactions between satellite cells and perivascular cells during growth and adulthood in physiological and pathological conditions.

 

Contact: peggy.lafuste {at} u-pec.fr

Peggy Lafuste

Stephanie 

Michineau, PhD

Associate Professor

Research Interests

I am working on the impact of environment on muscle biology and more specifically on the impact of pollution and hypoxia on satellite and endothelial cells.

 

Contact: michineau {at} u-pec.fr 

Stephanie Michineau

Olivier Stettler, PhD

Professor

Olivier Stettler

Marianne

Gervais-Taurel, PhD

Academic Researcher (CR)

Research Interests:

We are studying the impact of environmental stress, notably low oxygen and pollutants, on satellite cells, vascular cells and the myo-angiogenic coupling during muscle homeostasis and repair.

Contact: taurel {at} u-pec.fr

Marianne Gervais-Taurel

Advanced Technical Support

Frederic

Aurade, PhD

Molecular Biologist

Frederic Aurade

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Juliette

Berthier

Imaging Manager

Research Interests

I work on a specific preparation of biologic samples : The clearing. The purpose of the clearing is to make optically transparent a whole or thick biological sample so that it can be observed in depth.

 

Contact: Juliette.berthier {at} inserm.fr

Juliette Berthier

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Anais

Bleuzen

Gene editing assistant engineer

Research Interests

Being passionate about biotherapies, I have been involved in a gene therapy project for Duchenne muscular dystrophy, using the Crispr/Cas9 technology to restore or partially restore dystrophin.

 

Contact: anais.bleuzen {at} inserm.fr

Anais Bleuzen

Bernadette

Drayton-Libotte

Preclinical Model Manager

Research Interests

ES culture and maintenance

ES derivation and differentiation

Transgenesis (gene targetting via homologous recombination)

Bernadette Drayton-Libotte

Redouane Fodil

Biophysisist

Redouane Fodil

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Kaouthar

Kefi

Research Assistant

Kaouthar Kefi

Erica Kimber

Research Engineer

Research Interests:

I work with Dr Philippos Mourikis and his group on Notch signalling and its effect on the regulation of muscle satellite cell quiescence.

Contact: erica.kimber {at} inserm.fr

Erica Kimber

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Sylvie Manin

Research Assistant

Research Interests:

Involved in projects evaluating the pollution as environmental stress on muscle homeostasis in vivo as well as in lab logistics.

Contact: sylvie.manin {at} inserm.fr

Sylvie Manin

Post-docs

Matthew

Borok, PhD

Post-doc

Research Interests

I am using cytometric and viral approaches to investigate external and internal factors that regulate satellite cell quiescence.

Contact: matthew.borok {at} inserm.fr

Matthew Borok

Iwona Bronisz-Budzyńska, PhD

Post-doc

Research Interests

Duchenne Muscular Dystrophy pathology and treatment.

Contact: iwona.bronisz-budzynska {at} doctoral.uj.edu.pl

Iwona Bronisz-Budzyńska

Eleni

Chrysostomou, PhD

Post-doc

Research Interests

The main focus of my project is to understand how and why muscle stem cell quiescence is maintained and regulated by the extracellular matrix niche and specifically by Notch signalling.

 

Contact: chrysostomoueleni {at} gmail.com or  eleni.chrysostomou {at} inserm.fr

Eleni Chrysostomou

Audrey

Der Vartanian, PhD

Post-doc

Research Interests

The aim of my project is to identify the currently non-characterized impact of environment stress on muscle stem cells and decipher the cellular and molecular mechanisms involved, including the role of the AHR stress pathway.

Contact: audrey.der-vartanian {at} inserm.fr

Audrey Der Vartanian

Joana

Esteves de Lima, PhD

Post-doc

Research Interests

I am interested in understanding how the generation and maintenance of skeletal muscle progenitors/stem cells is regulated by epigenetic mechanisms.

 

Contact: joana.esteves-de-lima {at} inserm.fr

Joana Esteves de Lima

Alessio

Rotini, PhD

Post-doc

Research Interests

I aim to get insights into the cellular and molecular mechanisms by which the sympathetic neurons can putatively modulate the maintenance of SCs and pericytes in their myovascular niche.

Contact: alessio.rotini {at} inserm.fr

Alessio Rotini

Valentina

Taglietti, PhD

Post-doc

Research Interests:

I’m actively working on a new rat model for Duchenne muscular dystrophy to decipher the patho-physiological processes involved in DMD progression. Moreover, I'm currently studying the pathways underlying muscle regenerative defects of DMD on the path to therapeutic development.

Contact: valentina.taglietti {at} inserm.fr

Valentina Taglietti

PhD students

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Nassim Anis Ahmine

PhD student

Research Interests

With an engineering science background, I'm working on the multi-scale characterization of the mechanical properties of murine preclinical models in the context of the DMD disease. To reach this aim, I implement different experimental approaches as Traction Force Microscopy and Atomic Force Microscopy.

 

Contact: ahminenassimanis {at} gmail.com

Nassim Anis Ahmine

Reem

Bou-Akar

PhD student

Research Interests

I’m differentiating ESCs towards the myogenic lineage. Exploring this population, I plan to reveal new direct targets of upstream regulators of myogenesis.

 

Contact: reem.abou.akar {at} gmail.com

Reem Bou-Akar

Christelle 

Dubois

PhD student

Research Interests

My project is about the impact of environmental stress on the vascularisation of skeletal muscle, using exposure to a pollutant (TCDD) and chronic activation of the AHR stress-response pathway.

Contact: dubois2.christelle {at} gmail.com

Christelle Dubois

Perla 

Geara

PhD student

Research Interests

Genetic and  molecular characterization of the role of the Krüpple - like factor KLF4 in adult skeletal muscle stem cells.

 

Contact: perla.geara {at} inserm.fr

Perla Geara

Stamatia

Gioftsidi

PhD student

Research Interests

Establishment and regulation of quiescence on muscle stem cells.

Stamatia Gioftsidi

Nioosha Nekooie-Marnany

PhD student

Research Interests:

My aim is to establish the critical role of metabolites on each step of developmental neural crest cells: delamination, migration and differentiation.

Contact: nioosha.nekooie-marnany {at} inserm.fr

Nioosha Nekooie-Marnany

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Mathilde

Rodrigues

PhD student

Research Interests

Evaluation of the impact of a combination of standard treatment and innovative gene therapy in a rat preclinical model of Duchenne Muscular Dystrophy.

 

 

Contact: mathilde.rodrigues16 {at} gmail.com

Mathilde Rodrigues

Associated members

Leo

Machado

PhD student

Research Interests

I work in understanding how cells react to dissociation and subsequently promote ubiquitous and cell-specific transcriptional programs with a specific interest in skeletal muscle stem cells.

 

Contact: leo.machado {at} orange.fr

Leo Machado

Joseph

Touma

PhD student

Research Interests

I'm working on the characterization of muscle stem cells status and capacities in human samples of lower limn skeletal muscle from patients presenting peripheral arterial disease (PAD) and their relation to endothelial cells under the effect of ischemia. 

 

Contact: josephtouma.md {at} gmail.com

Joseph Touma