RELAIX LAB
PEOPLE
A Collaborative & International Group
Group leader & Management
Fred
RELAIX
Group Leader
My research programme aims at deciphering the mechanisms underlying skeletal muscle maintenance and function in physiological or pathogenic conditions such as Duchenne Muscular Dystrophy, preclinical modelling and establishment of innovative therapy with a strong focus on muscle stem cells development and function, impact of environmental stress, muscle stem cell heterogeneity, metabolism and interactions with the niche and local environment.
Contact: frederic.relaix {at} inserm.fr
Lila
BENDAMECHE
Financial Assistant
Financial support to the team for service/product ordering, budgeting, grant follow-up, and new recruits.
Despoina
MADEMTZOGLOU
Project Manager
Excited to discuss satellite cell-, regeneration-, dystrophy-related projects in the lab and to write grant applications, reports, and conference proposals for these topics.
Contact: dmademtz {at} gmail.com
Academic Researchers (CR)
Marianne
GERVAIS-TAUREL
Academic Researcher (CR)
In my group we are studying the impact of environmental stress, notably low oxygen and pollutants, on satellite cells, vascular cells and the myo-angiogenic coupling during muscle homeostasis and repair.
Contact: taurel {at} u-pec.fr
Philippos
MOURIKIS
Academic Researcher (CR)
Regulation of satellite cell quiescence with a focus on Notch signallng. Using innovative cell isolation techniques, our aim is to identify and characterize the factors that drive satellite cells into quiescence (development/regeneration), maintain them at this cell state during homeostasis, but also the factors that ignite their activation (regeneration and pathological conditions).
Contact: philippos.mourikis {at} inserm.fr
Associate Professors
Peggy
LAFUSTE
Associate Professor
Trying to decipher interactions between satellite cells and perivascular cells during growth and adulthood in physiological and pathological conditions.
Contact: peggy.lafuste {at} u-pec.fr
Stephanie
MICHINEAU
Associate Professor
I am working on the impact of environment on muscle biology and more specifically on the impact of pollution and hypoxia on satellite and endothelial cells.
Contact: michineau {at} u-pec.fr
Molecular Engineers
Frederic
AURADE
Molecular Engineer
Bernadette
DRAYTON-LIBOTTE
Preclinical Model Manager
ES culture and maintenance
ES derivation and differentiation
Transgenesis (gene targetting via homologous recombination)
Juliette
BERTHIER
Molecular Engineer
I work on a specific preparation of biologic samples : The clearing. The purpose of the clearing is to make optically transparent a whole or thick biological sample so that it can be observed in depth.
Contact: Juliette.berthier {at} inserm.fr
Post-docs
Matthew
BOROK
Post-doc
I am using mass cytometry to study all populations participating in muscle regeneration, and investigating signals involved in macrophage polarization.
Contact: matthew.borok {at} inserm.fr
Audrey
DER VARTANIAN
Post-doc
The aim of my project is to identify the currently non-characterized impact of environment stress on muscle stem cells and decipher the cellular and molecular mechanisms involved, including the role of the AHR stress pathway.
Contact: audrey.der-vartanian {at} inserm.fr
Joana
ESTEVES DE LIMA
Post-doc
I am interested in understanding how the generation and maintenance of skeletal muscle progenitors/stem cells is regulated by epigenetic mechanisms.
Contact: joana.esteves-de-lima {at} inserm.fr
Sergio
PEREZ DIAZ
Post-doc
Unveiling the communication code between the adipose tissue and muscle progenitors in health and disease.
Contact: sergio.perez-diaz {at} inserm.fr
Alessio
ROTINI
Post-doc
I aim to get insights into the cellular and molecular mechanisms by which the sympathetic neurons can putatively modulate the maintenance of SCs and pericytes in their myovascular niche.
Contact: alessio.rotini {at} inserm.fr
Valentina
TAGLIETTI
Post-doc
Decipher the relationship between Pax3 and the Dioxin receptor, named Aryl hydrocarbon receptor (AhR), during craniofacial development. In addition, I’m actively studying the role of Pax3 and Pax7 in regulating the gene regulatory network of somites and crest cells during evolution.
Contact: valentina.taglietti {at} inserm.fr
PhD students
I’m using ESCs to generate myogenic progenitors that express Pax3, a key upstream regulator of myogenesis. Exploring this population, I plan to reveal new direct targets of Pax3.
Contact: reem.abou.akar {at} gmail.com
Reem
BOU-AKAR
PhD student
Christelle
DUBOIS
PhD student
My project is about the impact of environmental stress on the vascularisation of skeletal muscle, using exposure to a pollutant (TCDD) and chronic activation of the AHR stress-response pathway.
Contact: dubois2.christelle {at} gmail.com
Perla
GEARA
PhD student
Genetic and molecular characterization of the role of the Krüpple - like factor KLF4 in adult skeletal muscle stem cells
Contact: perla.geara {at} inserm.fr
Stamatia
GIOFTSIDI
PhD student
Establishment and regulation of quiescence on muscle stem cells.
Zeynab
KOUMAIHA
PhD student
I worked on multiple subjects during my PhD:
-
Pericytes and the relationship between the microvascular niche and the satellite cells
-
High sucrose diet induced obesity and its effect on homeostasis and regeneration of the skeletal muscle
-
HMADS as a support regeneration tool for skeletal muscle
Contact: zeynab.koumaiha {at} inserm.fr
Leo
MACHADO
PhD student
I work in understanding how cells react to dissociation and subsequently promote ubiquitous and cell-specific transcriptional programs with a specific interest in skeletal muscle stem cells.
Contact: leo.machado {at} orange.fr
Marie
QUETIN
PhD student
I’m interested in the effect of hypoxia on skeletal muscle repair and on muscle stem cell fate.
Contact: marie.quetin {at} gmail.com
I'm working on the characterization of muscle stem cells status and capacities in human samples of lower limn skeletal muscle from patients presenting peripheral arterial disease (PAD) and their relation to endothelial cells under the effect of ischemia.
Contact: josephtouma.md {at} gmail.com
