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Relaix Lab publications since 2014


Relaix Lab publications since 2014


Borok M, Didier N, Gattazzo F, Ozturk T, Corneau A, Rouard H, Relaix F. Progressive and coordinated mobilization of the skeletal muscle niche throughout tissue repair revealed by single-cell proteomic analysis. Cells. 10(4): 744. PMID: 33800595

Machado L, Geara P, Camps J, Dos Santos M, Teixeira-Clerc F, Van Herck J, Varet H, Legendre R, Pawlotsky JM, Sampaolesi M, Voet T, Maire P, Relaix F, Mourikis P. Tissue damage induces a conserved stress response that initiates quiescent muscle stem cell activation. Cell Stem Cell. S1934-5909(21)00017-5. PMID: 33609440


Prola A, Blondelle J, Vandestienne A, Piquereau J, Denis RGP, Guyot S, Chauvin H, Mourier A, Maurer M, Henry C, Khadhraoui N, Gallerne C, Molinie T, Courtin G, Guillaud L, Gressette M, Solgadi A, Dumont F, Castel J, Ternacle J, Demarquoy J, Malgroyre A, Loulmann N, Derumeaux G, Giraud MF, Joubert F, Beksier V, Luquet S, Relaix F, Tiret L, Pilot-Storck F. Cardiolipin content controls mitochondrial coupling and energetic efficiency in muscle. Sci Adv. 7(1):eabd6322. PMID: 30194302

Relaix F, Bencze M, Borok MJ, Der Vartanian A, Gattazzo F, Mademtzoglou D, Perez-Diaz S, Prola A, Reyes-Fernandez PC, Rotini A, Taglietti V. Perspectives on skeletal muscle stem cells. Nat Commun. 12(1):692. PMID: 33514709

Levoux J, Prola A, Lafuste P, Gervais M, Chevallier N, Koumaiha Z, Kefi K, Braud L, Schmitt A, Yacia A, Schirmann A, Hersant B, Sid-Ahmed M, Ben Larbi S, Komrskova K, Rohlena J, Relaix F, Neuzil J, Rodriguez AM. Platelets facilitate the wound-healing capability of mesenchymal stem cells by mitochondrial transfer and metabolic reprogramming. Cell Metab. S1550-4131(20):30661-6. PMID: 3340911


Hou C, Durrleman C, Periou B, Barnerias C, Bodemer C, Desguerre I, Quartier P, Melki I, Rice GI, Rodero MP, Charuel JL, Relaix F, Bader-Meunier B, Authier FJ, Gitiaux C. From diagnosis to prognosis: Revisiting the meaning of muscle ISG15 overexpression in juvenile inflammatory myopathies. Arthritis Rheumatol. PMID: 33314705

Gonzalez Curto G, Der Vartanian A, Frarma YE, Manceau L, Baldi L, Prisco S, Elarouci N, Causeret F, Korenkov D, Rigolet M, Aurade F, De Reynies A, Contremoulins V, Relaix F, Faklaris O, Briscoe J, Gilardi-Hebenstreit P, Ribes V. The PAX-FOXO1s trigger fast trans-differentiation of chick embryonic neural cells into alveolar rhabdomyosarcoma with tissue invasive properties limited by S phase entry inhibition. PLoS Genet16(11):e1009164. PMID: 33175861

Dos Santos M, Backer S, Saintpierre B, Izac B, Andrieu M, Letourneur F, Relaix F, Sotiropoulos A, Maire P. Single-nucleus RNA-seq and FISH identify coordinated transcriptional activity in mammalian myofibers. Nat Commun. 11(1):5102. PMID: 33037211

Gattazzo F, Laurent B, Relaix F, Rouard H, Didier N. Distinct phases of postnatal skeletal muscle growth govern the progressive establishment of muscle stem cell quiescence. Stem Cell Reports. S2213-6711(20)30288-5. PMID: 32763161

Besse A, Astord S, Marais T, Roda M, Giroux B, Lejeune FX, Relaix F, Smeriglio P, Barkats M, Biferi MG. AAV9-mediated expression of SMN restricted to neurons does not rescue the Spinal Muscular Atrophy phenotype in mice. Mol Ther. 28(8). 1887-1901. PMID: 32470325

Borok MJ, Mademtzoglou D, Relaix F. Bu-M-P-ing iron: How BMP signaling regulates muscle growth and regeneration. J Dev Biol. 8(1). pii: E4. PMID: 32053985


Yvernogeau L, Gautier R, Petit L, Khoury H, Relaix F, Ribes V, Sang H, Charbord P, Souyri M, Robin C, Jaffredo T. In vivo generation of haematopoietic stem/progenitor cells from bone marrow-derived haemogenic endothelium. Nat Cell Biol. 21(11): 1334-1345. PMID: 31685991

Reyes-Fernandez PC, Periou B, Decrouy X, Relaix F, Authier FJ. Automated image-analysis method for the quantification of fiber morphometry and fiber type population in human skeletal muscle. Skelet Muscle. 9(1): 15. PMID: 31133066

Der Vartanian A, Quétin M, Michineau S, Auradé F, Hayashi S, Dubois C, Rocancourt D, Drayton-Libotte B, Szegedi A, Buckingham M, Conway SJ, Gervais M, Relaix F. Pax3 confers functional heterogeneity in skeletal muscle stem cell responses to environmental stressCell Stem Cell. pii: S1934-5909(19)30118-3. PMID: 31006622


Hou C, Baba-Amer Y, Bencze M, Relaix F, Authier JF. [The effect of interferon-gamma on skeletal muscle cell biology]. Med Sci (Paris). 34 Hors série n°2:35-38. PMID: 30418144

Mademtzoglou D, Asakura Y, Borok MJ, Alonso-Martin S, Mourikis P, Kodaka Y, Mohan A, Asakura A, Relaix F. Cellular localization of the cell cycle inhibitor Cdkn1c controls growth arrest of adult skeletal muscle stem cellsElife. 7. pii: e33337. PMID: 30284969

Taglietti V, Angelini G, Mura G, Bonfanti C, Caruso E, Monteverde S, Le Carrou G, Tajbakhsh S, Relaix F, Messina G. RhoA and ERK signalling regulate the expression of the transcription factor Nfix in myogenic cellsDevelopment. 145(21). PMID: 30266829

Morgan JE, Prola A, Mariot V, Pini V, Meng J, Hourde C, Dumonceaux J, Conti F, Relaix F, Authier FJ, Tiret L, Muntoni F, Bencze M. Necroptosis mediates myofibre death in dystrophin-deficient miceNat Commun. 9(1): 3655. PMID: 30194302

Alonso-Martin S, Auradé F, Mademtzoglou D, Rochat A, Zammit PS, Relaix F. SOXF factors regulate murine satellite cell self-renewal and function through inhibition of β-catenin activityElife. 7. pii: e26039. PMID: 29882512

Baghdadi MB, Castel D, Machado L, Fukada SI, Birk DE, Relaix F, Tajbakhsh S, Mourikis P. Reciprocal signalling by Notch-Collagen V-CALCR retains muscle stem cells in their nicheNature. 557(7707):714-718. PMID: 29795344

Relaix F, Machado L. Waking up muscle stem cells: PI3K signalling is ringing. EMBO J. 37(8). pii: e99297. PMID: 29581098


Banerji CRS, Panamarova M, Hebaishi H, White RB, Relaix F, Severini S, Zammit PS. PAX7 target genes are globally repressed in facioscapulohumeral muscular dystrophy skeletal muscleNat Commun. 8(1):2152. PMID: 29255294

Machado L, Esteves de Lima J, Fabre O, Proux C, Legendre R, Szegedi A, Varet H, Ingerslev LR, Barrès R, Relaix F, Mourikis PIn situ fixation redefines quiescence and early activation of skeletal muscle stem cellsCell Rep. 21(7):1982-1993. PMID: 29141227

Vallecillo-García P, Orgeur M, Vom Hofe-Schneider S, Stumm J, Kappert V, Ibrahim DM, Börno ST, Hayashi S, Relaix F, Hildebrandt K, Sengle G, Koch M, Timmermann B, Marazzi G, Sassoon DA, Duprez D, Stricker S. Odd skipped-related 1 identifies a population of embryonic fibro-adipogenic progenitors regulating myogenesis during limb development. Nat Commun. 8(1): 1218. PMID: 29084951

Stantzou A, Schirwis E, Swist S, Alonso-Martin S, Polydorou I, Zarrouki F, Mouisel E, Beley C, Julien A, Le Grand F, Garcia L, Colnot C, Birchmeier C, Braun T, Schuelke M, Relaix F, Amthor H. BMP signaling regulates satellite cell-dependent postnatal muscle growthDevelopment. 144(15): 2737-2747. PMID: 28694257

Gard C, Gonzalez Curto G, Frarma YE, Chollet E, Duval N, Auzié V, Auradé F, Vigier L, Relaix F, Pierani A, Causeret F, Ribes V. Pax3- and Pax7-mediated Dbx1 regulation orchestrates the patterning of intermediate spinal interneurons. Dev Biol. 432(1): 24-33. PMID: 28625870

Scionti I, Hayashi S, Mouradian S, Girard E, Esteves de Lima J, Morel V, Simonet T, Wurmser M, Maire P, Ancelin K, Metzger E, Schüle R, Goillot E, Relaix F, Schaeffer L. LSD1 controls timely MyoD expression via MyoD core enhancer transcriptionCell Rep. 18(8): 1996-2006. PMID: 28228264


Mademtzoglou D, Alonso-Martin S, Chang TH, Bismuth K, Drayton-Libotte B, Aurade F, Relaix F. A p57 conditional mutant allele that allows tracking of p57-expressing cells.Genesis. 55(4). PMID: 28196404


Hayashi S, Manabe I, Suzuki Y, Relaix F, Oishi Y. Klf5 regulates muscle differentiation by directly targeting muscle-specific genes in cooperation with MyoD in miceElife. 2016;5. PMID: 27743478


Machado L, Relaix F. Heterochromatin compaction is regulated by Suv4-20h1 to maintains skeletal muscle stem cells quiescence. Stem Cell Investig. 2016;3:23. PMID: 27488816

Alonso-Martin S, Rochat A, Mademtzoglou D, Morais J, de Reyniès A, Auradé F, Chang TH, Zammit PS, Relaix FGene expression profiling of muscle stem cells identifies novel regulators of postnatal myogenesisFront Cell Dev Biol. 2016;4:58. PMID: 27446912

Mourikis P, Relaix F. Activated muscle satellite cells chase ghostsCell Stem Cell18(2): 160-2. PMID: 26849298

Smeriglio P, Alonso-Martin S, Masciarelli S, Madaro L, Iosue I, Marrocco V, Relaix F, Fazi F, Marazzi G, Sassoon DA, Bouché M. Phosphotyrosine phosphatase inhibitor bisperoxovanadium endows myogenic cells with enhanced muscle stem cell functions via epigenetic modulation of Sca-1 and Pw1 promoters. FASEB J. 30(4): 1404-15. PMID: 26672000


Zalc A, Rattenbach R, Auradé F, Cadot B, Relaix F. Pax3 and Pax7 play essential safeguard functions against environmental stress-induced birth defects. Dev Cell. 33(1): 56-66. PMID: 25800090

Buckingham M, Relaix F. PAX3 and PAX7 as upstream regulators of myogenesis. Semin Cell Dev Biol. 44: 115-125. PMID: 26424495

Kostallari E, Baba-Amer Y, Alonso-Martin S, Ngoh P, Relaix F, Lafuste P, Gherardi RK. Pericytes in the myovascular niche promote post-natal myofiber growth and satellite cell quiescenceDevelopment. 2015;142(7):1242-53. PMID: 25742797

Chal J, Oginuma M, Al Tanoury Z, Gobert B, Sumara O, Hick A, Bousson F, Zidouni Y, Mursch C, Moncuquet P, Tassy O, Vincent S, Miyanari A, Bera A, Garnier JM, Guevara G, Hestin M, Kennedy L, Hayashi S, Drayton B, Cherrier T, Gayraud-Morel B, Gussoni E, Relaix F, Tajbakhsh S, Pourquié O. Differentiation of pluripotent stem cells to muscle fiber to model Duchenne muscular dystrophyNat Biotechnol. 33(9): 962-969. PMID: 26237517

Blondelle J, Ohno Y, Gache V, Guyot S, Storck S, Blanchard-Gutton N, Barthélémy I, Walmsley G, Rahier A, Gadin S, Maurer M, Guillaud L, Prola A, Ferry A, Aubin-Houzelstein G, Demarquoy J, Relaix F, Piercy RJ, Blot S, Kihara A, Tiret L, Pilot-Storck F. HACD1, a regulator of membrane composition and fluidity, promotes myoblast fusion and skeletal muscle growthJ Mol Cell Biol. 2015;7(5):429-40. PMID: 26160855


Mayeuf-Louchart A, Lagha M, Danckaert A, Rocancourt D, Relaix F, Vincent SD, Buckingham M. Notch regulation of myogenic versus endothelial fates of cells that migrate from the somite to the limb. Proc Natl Acad Sci U S A. 111(24): 8844-8849. PMID: 24927569

Zalc A, Hayashi S, Auradé F, Bröhl D, Chang T, Mademtzoglou D, Mourikis P, Yao Z, Cao Y, Birchmeier C, Relaix F. Antagonistic regulation of p57kip2 by Hes/Hey downstream of Notch signaling and muscle regulatory factors regulates skeletal muscle growth arrestDevelopment. 141(14): 2780-2790. PMID: 25005473



Selected publications until 2014

Lagha M, Mayeuf-Louchart A, Chang T, Montarras D, Rocancourt D, Zalc A, Kormish J, Zaret KS, Buckingham ME, Relaix F. Itm2a is a Pax3 target gene, expressed at sites of skeletal muscle formation in vivoPLoS One. 2013; 8(5): e63143. PMID: 23650549

Relaix F, Demignon J, Laclef C, Pujol J, Santolini M, Niro C, Lagha M, Rocancourt D, Buckingham M, Maire P. Six homeoproteins directly activate Myod expression in the gene regulatory networks that control early myogenesisPLoS Genet. 2013; 9(4): e1003425. PMID: 23637613

Calhabeu F, Hayashi S, Morgan JE, Relaix F, Zammit PS. Alveolar rhabdomyosarcoma-associated proteins PAX3/FOXO1A and PAX7/FOXO1A suppress the transcriptional activity of MyoD-target genes in muscle stem cellsOncogene. 2013; 32(5): 651-62. PMID: 22710712

Relaix F, Zammit PS. Satellite cells are essential for skeletal muscle regeneration: the cell on the edge returns centre stageDevelopment. 2012; 139(16): 2845-56. PMID: 22833472

Havis E, Coumailleau P, Bonnet A, Bismuth K, Bonnin MA, Johnson R, Fan CM, Relaix F, Shi DL, Duprez D. Sim2 prevents entry into the myogenic program by repressing MyoD transcription during limb embryonic myogenesisDevelopment. 2012; 139(11): 1910-20. PMID: 22513369

Van Ho AT, Hayashi S, Bröhl D, Auradé F, Rattenbach R, Relaix F. Neural crest cell lineage restricts skeletal muscle progenitor cell differentiation through Neuregulin1-ErbB3 signalingDev Cell. 2011; 21(2): 273-87. PMID: 21782525

Hayashi S, Rocancourt D, Buckingham M, Relaix FLack of in vivo functional compensation between Pax family groups II and III in rodentsMol Biol Evol. 2011; 28(10): 2787-98. PMID: 21512107

Lagha M, Sato T, Regnault B, Cumano A, Zuniga A, Licht J, Relaix F, Buckingham M. Transcriptome analyses based on genetic screens for Pax3 myogenic targets in the mouse embryoBMC Genomics. 2010; 11: 696. PMID: 21143873

Lagha M, Brunelli S, Messina G, Cumano A, Kume T, Relaix F, Buckingham ME. Pax3:Foxc2 reciprocal repression in the somite modulates muscular versus vascular cell fate choice in multipotent progenitorsDev Cell. 2009; 17(6): 892-9. PMID: 20059958

Lagha M, Sato T, Bajard L, Daubas P, Esner M, Montarras D, Relaix F, Buckingham M. Regulation of skeletal muscle stem cell behavior by Pax3 and Pax7Cold Spring Harb Symp Quant Biol. 2008; 73: 307-15. PMID: 19022756

Lagha M, Kormish JD, Rocancourt D, Manceau M, Epstein JA, Zaret KS, Relaix F, Buckingham ME. Pax3 regulation of FGF signaling affects the progression of embryonic progenitor cells into the myogenic programGenes Dev. 2008; 22(13): 1828-37. PMID: 18593883

Bajard L, Relaix F, Lagha M, Rocancourt D, Daubas P, Buckingham ME. A novel genetic hierarchy functions during hypaxial myogenesis: Pax3 directly activates Myf5 in muscle progenitor cells in the limbGenes Dev. 2006; 20(17): 2450-6

Zammit PS, Relaix F, Nagata Y, Ruiz AP, Collins CA, Partridge TA, Beauchamp JR. Pax7 and myogenic progression in skeletal muscle satellite cellsJ Cell Sci. 2006; 119(Pt 9): 1824-32. PMID: 16608873

Relaix F, Montarras D, Zaffran S, Gayraud-Morel B, Rocancourt D, Tajbakhsh S, Mansouri A, Cumano A, Buckingham M. Pax3 and Pax7 have distinct and overlapping functions in adult muscle progenitor cellsJ Cell Biol. 2006; 172(1): 91-102. PMID: 16380438

Montarras D, Morgan J, Collins C, Relaix F, Zaffran S, Cumano A, Partridge T, Buckingham M. Direct isolation of satellite cells for skeletal muscle regenerationScience. 2005; 309(5743): 2064-7. PMID: 16141372

Relaix F, Rocancourt D, Mansouri A, Buckingham M. A Pax3/Pax7-dependent population of skeletal muscle progenitor cellsNature. 2005; 435(7044): 948-53. PMID: 15843801

Relaix F, Rocancourt D, Mansouri A, Buckingham M. Divergent functions of murine Pax3 and Pax7 in limb muscle developmentGenes Dev. 2004; 18(9): 1088-105. PMID: 15132998

Relaix F, Polimeni M, Rocancourt D, Ponzetto C, Schäfer BW, Buckingham M. The transcriptional activator PAX3-FKHR rescues the defects of Pax3 mutant mice but induces a myogenic gain-of-function phenotype with ligand-independent activation of Met signaling in vivoGenes Dev. 2003; 17(23): 2950-65. PMID: 14665670

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