The Relaix lab seeks to understand the fundamendal mechanisms of development and regeneration, using skeletal muscle as a model tissue.
Our lab is part of the BNMS Team, directed by Fred Relaix.
Machado et al. Tissue damage induces a conserved stress response that initiates quiescent muscle stem cell activation. Cell Stem Cell, 2021
Der Vartanian et al. (...), Relaix. PAX3 confers functional heterogeneity in skeletal muscle stem cell responses to environmental stress. Cell Stem Cell, 2019
Baghdadi et al. Reciprocal signalling by Notch-Collagen V-CALCR retains muscle stem cells in their niche. Nature, 2018
Our lab is an active member of the stem-cell-focused consortia:
April 2021: We welcome Iwona Bronisz-Budzyńska in the team for her post-doc work.
April 2021: Our study on "M-Cadherin is a PAX3 target during myotome patterning" is out at Front Cell Dev Biol
March 2021: Our study on "Progressive and coordinated mobilization of the skeletal muscle niche throughout tissue repair revealed by single-cell proteomic analysis" is out at Cells
February 2021: Our study on "Tissue damage induces a conserved stress response that initiates quiescent muscle stem cell activation" is out at Cell Stem Cell
January 2021: Our study on "Cardiolipin content controls mitochondrial coupling and energetic efficiency in muscle" is out at Science Advances
January 2021: Our study on "Platelets facilitate the wound-healing capability of mesenchymal stem cells by mitochondrial transfer and metabolic reprogramming" is out at Cell Metabolism
January 2021: We welcome Marine Ledoux, Gwladys Berge & Diane Saindrenan in the team for their masters theses.
December 2020: In support of the 2020 AFM-Telethon fundraising campaign to support patients and research related to neuromuscular disorders, we have set up a collection page for Telethon.
November 2020: Our team's activities are summarized in videos that we will start posting on our twitter account @RelaixLab. Follow us to find out more about our research.
November 2020: We welcome Lea Rivera (masters student) in the team.
October 2020: Thank you to Pascal Maire for the collaboration on using single nucleus sequencing on muscle samples. Frst joint paper is now published in Nat Commun, showing coordinated transcription within myofibers.
October 2020: Valentina presenting poster in the WMS virtual meeting. Congratulations to her for the conference prize!
October 2020: We welcome Mathilde Rodrigues (PhD student) in the team
September 2020: We welcome Jules Gilet (associate professor), Sylvie Manin (assistant engineer), Eleni Chrysostomou (post-doc) & Erica Kimber (assistant engineer), in the team.
August 2020: The EMBOmuscle2020 meeting co-organized by Fred, is passing to a hybrid (online + on-site) format
July 2020: You can find our study on "Distinct phases of postnatal skeletal muscle growth govern the progressive establishment of muscle stem cell quiescence" in Stem Cell Reports here
May 2020: Despoina presenting poster in the ASGCT virtual meeting
April 2020: Fred giving talk in the Muscle Regeneration in Isolation virtual meeting
April 2020: We welcome Anais Bleuzen (assistant engineer) in the team
March 2020: Our team passed to remote work mode in view of the COVID-19 epidemic:
- Sending material to our collaborators will be on hold for a while
- Delivery of recent orders is possible thanks to the continuing activity plan of IMRB
- We expect to transform all those stocked data to submitted papers #CoronavirusResolutions
March 2020: Our study on "Platelets promote pro-angiogenic activity of mesenchymal stem cells via mitochondrial transfer and metabolic reprogramming" is available on Cell Metabolism sneak peek here
February 2020: Our study on "Skeletal muscle tissue damage leads to a conserved stress response and stem cell-specific adaptive transitions" is available on CellStemCell sneak peek here
February 2020: Dr. Han Li visited the lab and presented her work on reprogramming and cellular plasticity
January 2020: We are grateful to AFM-Telethon for renewing their trust to our Translamuscle Strategic Pole and supporting our translational research on neuromuscular disorders
December 2019: Prof. Elazar Zelzer visited the lab and presented interesting results on the bone-tendon-muscle system
December 2019: Marie defended her PhDs
November 2019: Multiple team members visited French schools to discuss gene & cell therapy (see highlights)
November 2019: Zeynab and Leo defended their PhDs
October 2019: Poster prize to Alessio in the 3rd International Conference on Stem Cells meeting (Chania, Greece)
September 2019: Fred giving talk in the Frontiers in Myogenesis meeting (San Jose, Costa Rica)
July 2019: We organized the first BNMS retreat to exchange ideas on results & scientific strategies of all groups of the BNMS team
June 2019: Philippos promoted to DR2 at CNRS
June 2019: Philippos giving talk and Joana presenting poster in GRC Myogenesis (Lucca, Italy)
May 2019: Fred giving talk in the Institute of Genetics and Biophysics (Napoli, Italy)
April 2019: You can find our latest publication (highlights on the right) in Cell Stem Cell here
March 2019: Fred giving talk in the Myology 2019 meeting - many of our PhD & post-docs presenting posters (Bordeaux, France)
Our team is developing a research program for the understanding and treatment of neuromuscular disorders. We are grateful to AFM-Telethon for the generous support of this program through the Strategic Pole "Translamuscle".
PAX3 confers functional heterogeneity in skeletal muscle stem cell responses to environmental stress
Pax3 expression determines satellite cell responses to AHR-dependent environmental stress
TCDD exposure elicits aberrant survival, activation, and myofiber fusion in Pax3- satellite cells.
Pax3-dependent G(alert) and detox pathways protect satellite cells from environmental stress
Campaign "1000 researchers visit schools"
11 members of our team visited 12 schools in November 2019 in the frame of a campaign conceptualized and coordinated by AFM-Telethon
we interacted with ~1,500 students to discuss the latest advancements of gene and cell therapy as well as science careers