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The Relaix lab seeks to understand the fundamendal mechanisms of development and regeneration, using skeletal muscle as a model tissue. 

Find out more

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Our lab is part of the BNMS Team, directed by Fred Relaix. 

Our research

Recent publications

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Our lab is an active member of the stem-cell-focused consortia: 

News

April 2021: We welcome Iwona Bronisz-Budzyńska in the team for her post-doc work.

April 2021: Our study on "M-Cadherin is a PAX3 target during myotome patterning" is out at Front Cell Dev Biol

March 2021: Our study on "Progressive and coordinated mobilization of the skeletal muscle niche throughout tissue repair revealed by single-cell proteomic analysis" is out at Cells

February 2021: Our study on "Tissue damage induces a conserved stress response that initiates quiescent muscle stem cell activation" is out at Cell Stem Cell

January 2021: Our study on "Cardiolipin content controls mitochondrial coupling and energetic efficiency in muscle" is out at Science Advances

January 2021: Our study on "Platelets facilitate the wound-healing capability of mesenchymal stem cells by mitochondrial transfer and metabolic reprogramming" is out at Cell Metabolism

January 2021: We welcome Marine Ledoux, Gwladys Berge & Diane Saindrenan in the team for their masters theses.

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December 2020: In support of the 2020 AFM-Telethon fundraising campaign to support patients and research related to neuromuscular disorders, we have set up a collection page for Telethon. 

November 2020: Our team's activities are summarized in videos that we will start posting on our twitter account @RelaixLab. Follow us to find out more about our research.

November 2020: We welcome Lea Rivera (masters student) in the team.

October 2020: Thank you to Pascal Maire for the collaboration on using single nucleus sequencing on muscle samples. Frst joint paper is now published in ⁦ Nat Commun, showing coordinated transcription within myofibers.

October 2020: Valentina presenting poster in the WMS virtual meeting. Congratulations to her for the conference prize!

October 2020: We welcome Mathilde Rodrigues (PhD student) in the team

September 2020: We welcome Jules Gilet (associate professor), Sylvie Manin (assistant engineer), Eleni Chrysostomou (post-doc) & Erica Kimber (assistant engineer), in the team.

August 2020: The EMBOmuscle2020 meeting co-organized by Fred, is passing to a hybrid (online + on-site) format

July 2020: You can find our study on "Distinct phases of postnatal skeletal muscle growth govern the progressive establishment of muscle stem cell quiescence" in Stem Cell Reports here

May 2020: Despoina presenting poster in the ASGCT virtual meeting

April 2020: Fred giving talk in the Muscle Regeneration in Isolation virtual meeting

April 2020: We welcome Anais Bleuzen (assistant engineer) in the team

March 2020: Our team passed to remote work mode in view of the COVID-19 epidemic:
- Sending material to our collaborators will be on hold for a while
- Delivery of recent orders is possible thanks to the continuing activity plan of IMRB
- We expect to transform all those stocked data to submitted papers #CoronavirusResolutions

March 2020: Our study on "Platelets promote pro-angiogenic activity of mesenchymal stem cells via mitochondrial transfer and metabolic reprogramming" is available on Cell Metabolism sneak peek here

February 2020: Our study on "Skeletal muscle tissue damage leads to a conserved stress response and stem cell-specific adaptive transitions" is available on CellStemCell sneak peek here

February 2020: Dr. Han Li visited the lab and presented her work on reprogramming and cellular plasticity

January 2020: We​ are grateful to AFM-Telethon for renewing their trust to our Translamuscle Strategic Pole and supporting our translational research on neuromuscular disorders

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December 2019: Prof. Elazar Zelzer visited the lab and presented interesting results on the bone-tendon-muscle system

December 2019: Marie defended her PhDs 

November 2019: Multiple team members visited French schools to discuss gene & cell therapy (see highlights)

November 2019: Zeynab and Leo defended their PhDs 

October 2019: Poster prize to Alessio in the 3rd International Conference on Stem Cells meeting (Chania, Greece) 

September 2019: Fred giving talk in the Frontiers in Myogenesis meeting (San Jose, Costa Rica) 

July 2019: We organized the first BNMS retreat to exchange ideas on results & scientific strategies of all groups of the BNMS team

June 2019: Philippos promoted to DR2 at CNRS

June 2019: Philippos giving talk and Joana presenting poster in GRC Myogenesis (Lucca, Italy)

May 2019: Fred giving talk in the Institute of Genetics and Biophysics (Napoli, Italy)

April 2019: You can find our latest publication (highlights on the right) in Cell Stem Cell here

March 2019: Fred giving talk in the Myology 2019 meeting - many of our PhD & post-docs presenting posters (Bordeaux, France)

Highlights

Translamuscle

Our team is developing a research program for the understanding and treatment of neuromuscular disorders. We are grateful to AFM-Telethon for the generous support of this program through the Strategic Pole "Translamuscle".

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PAX3 confers functional heterogeneity in skeletal muscle stem cell responses to environmental stress

Highlights: 

  • Pax3 expression determines satellite cell responses to AHR-dependent environmental stress

  • TCDD exposure elicits aberrant survival, activation, and myofiber fusion in Pax3- satellite cells.

  • Pax3-dependent G(alert) and detox pathways protect satellite cells from environmental stress

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Campaign "1000 researchers visit schools"

Highlights: 

  • 11 members of our team visited 12 schools in November 2019 in the frame of a campaign conceptualized and coordinated by AFM-Telethon

  • we interacted with ~1,500 students to discuss the latest advancements of gene and cell therapy as well as science careers

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