RELAIX LAB
News from the Lab:
PAX3 defines a distinct muscle stem cell identity.
Some adult muscle stem cells keep expressing PAX3, a factor best known from embryonic development. We show they form a stable subpopulation, unevenly distributed across muscles independently of embryonic origin. These cells are primed to activate, proliferate and differentiate faster, and they depend on PAX3 to survive. PAX3 acts through SIX2, which is expressed only in PAX3-positive cells and rescues their survival when Pax3 is lost.
2026
Consortia
Our team is developing a research program for the understanding and treatment of neuromuscular disorders. We are grateful to AFM-Telethon for the generous support of this program through the Strategic Pole Translamuscle.
Our research
The Relaix lab seeks to understand the fundamental mechanisms of development, regeneration and pathology, using skeletal muscle as a model tissue. Find out more.
Our lab is linked to UPEC Health Faculty, INSERM (Institut Mondor de Recherche Biomédicale), ENVA, EFS & APHP.
News