Our research

The Relaix lab seeks to understand the fundamendal mechanisms of development, regeneration, and pathology, using skeletal muscle as a model tissue. 

Find out more

Our lab is linked to UPEC-Faculty of Medicine, INSERM (Mondor Biomedical Research Institute-IMRB, INSERM U955), ENVA, EFS, APHP.

Translamuscle

Our team is developing a research program for the understanding and treatment of neuromuscular disorders. We are grateful to AFM-Telethon for the generous support of this program through the Strategic Pole "Translamuscle".

Consortia

Our lab is an active member of the stem-cell-focused consortia: 

Revive.jpg

Campaign "1000 researchers visit schools"

Before the pandemic, we visited several schools around France in the frame of a campaign conceptualized and coordinated by AFM-Telethon. In 2019 alone, we interacted with ~1,500 students to discuss the latest advancements of gene and cell therapy as well as science careers

Twitter%25201000%2520chercheurs_edited_e

News

2021

June 2021

Publication

Our study on "HIRA stabilizes skeletal muscle lineage identity" is out at Nat Commun

April 2021

PhD defense

Aymeline defended her thesis

February 2021

Publication

Our study on "Tissue damage induces a conserved stress response that initiates quiescent muscle stem cell activation" is out at Cell Stem Cell

June 2021

Publication

Our study on "Unexpected contribution of fibroblasts to muscle lineage as a mechanism for limb muscle patterning" is out at Nat Commun

April 2021

Publication

Our study on "M-Cadherin is a PAX3 target during myotome patterning" is out at Front Cell Dev Biol

January 2021

Publication

Our study on "Platelets facilitate the wound-healing capability of mesenchymal stem cells by mitochondrial transfer and metabolic reprogramming" is out at Cell Metabolism

May 2021

Publication

Our study on "Stress relief: emerging methods to mitigate dissociation-induced artefacts." is out at Trend Cell Biol

April 2021

New team members

We welcome Iwona for her post-doc work and Léa for taking care of our neuromuscular physio-pathology models

January 2021

Publication

Our study on "Cardiolipin content controls mitochondrial coupling and energetic efficiency in muscle" is out at Science Advances

May 2021

Publication

Our study on "Direct contribution of skeletal muscle mesenchymal progenitors to bone repair" is out at Nat Commun

March 2021

Publication

Our study on "Progressive and coordinated mobilization of the skeletal muscle niche throughout tissue repair revealed by single-cell proteomic analysis" is out at Cells

January 2021

New team members

We welcome Marine, Gwladys & Diane in the team for their masters theses

2020

December 2020

Social engagement

In support of the 2020 AFM-Telethon fundraising campaign to support patients and research on neuromuscular disorders, we have set up a collection page for Telethon

October 2020

Conference

Valentina presenting poster in the WMS virtual meeting.

 

Congratulations to her for the conference prize!

August 2020

Conference update

The EMBO meeting co-organized by Fred, is passing to a hybrid (online + on-site) format

April 2020

New team member

We welcome Anais (assistant engineer) in the team

February 2020

Guest speaker

Dr. Han Li visited the lab and presented her work on reprogramming and cellular plasticity

November 2020

New team member

We welcome Lea Rivera in the team for her master thesis

October 2020

PhD defense

Nahed defended her thesis

July 2020

Publication

You can find our study on "Distinct phases of postnatal skeletal muscle growth govern the progressive establishment of muscle stem cell quiescence" in Stem Cell Reports here

March 2020

Covid-19

Passing to remote work mode:

- Sending material to our collaborators is on hold 

- Delivery of recent orders is still possible 

- We expect to transform all those stocked data to submitted papers

January 2020

Translamuscle II

We​ are grateful to AFM-Telethon for renewing their trust to our Translamuscle Strategic Pole and supporting our translational research on neuromuscular disorders

November 2020

Team video

Our team's activities are summarized in videos that we will start posting on our twitter account @RelaixLab. Follow us to find out more about our research

September 2020

Scientific Strategy

We initiate collaborative projects with the biotech Encefa, hosted in our lab at EnvA

May 2020

Conference

Despoina presenting poster in the ASGCT virtual meeting

March 2020

Preprint

Our study on "Platelets promote pro-angiogenic activity of mesenchymal stem cells via mitochondrial transfer and metabolic reprogramming" is available on Cell Metabolism sneak peek here

January 2020

Lab's organisation

Groups 3 (Tiret) & 4 (Blot) move into the new Auguste Chauveau building at EnvA

November 2020

Collaboration

Thank you to Pascal Maire for the collaboration on single nucleus sequencing of muscle samples. Frst joint paper is out in ⁦ Nat Commun, showing coordinated transcription within myofibers

September 2020

New team members

We welcome Eleni (post-doc), Jules (associate professor), Erica (assistant engineer), Sylvie (assistant engineer), Mélody (PhD student) & Mathilde (PhD student), in the team

April 2020

Seminar series

Fred giving talk in the Muscle Regeneration in Isolation virtual meeting

February 2020

Preprint

Our study on "Skeletal muscle tissue damage leads to a conserved stress response and stem cell-specific adaptive transitions" is available on CellStemCell sneak peek here

2019

December 2019

Guest speaker

Prof. Elazar Zelzer visited the lab and presented interesting results on the bone-tendon-muscle system

October 2019

New team member

We welcome Nabil in the team for his PhD

June 2019

Promotion

Philippos promoted to DR2 at CNRS

March 2019

Conference

Fred giving talk in the Myology 2019 meeting - many of our PhD & post-docs presenting posters (Bordeaux, France)

December 2019

PhD defense

Marie defended her PhD

October 2019

Conference

Poster prize to Alessio in the 3rd International Conference on Stem Cells meeting (Chania, Greece)

June 2019

Conference

Philippos giving talk and Joana presenting poster in GRC Myogenesis (Lucca, Italy)

 

November 2019

Outreach program

Multiple team members visited French schools to discuss gene & cell therapy (highlight above)

September 2019

Conference

Fred giving talk in the Frontiers in Myogenesis meeting (San Jose, Costa Rica) 

May 2019

Seminar

Fred giving talk in the Institute of Genetics and Biophysics (Napoli, Italy)

November 2019

PhD defenses

Zeynab & Leo defended their PhDs

July 2021

Retreat

We organized the first BNMS retreat to exchange ideas on results & scientific strategies of all groups of the BNMS team

April 2019

Publication

Our study on "PAX3 confers functional heterogeneity in skeletal muscle stem cell responses to environmental stress" is out in Cell Stem Cell